Interception Leaders
| Player | Team | POS | Def Int | IntYards | Int Lg | Def TDs |
|---|---|---|---|---|---|---|
 Minkah Fitzpatrick | PIT | FS, S | 10 | 146 | 121 | 0 |
| Xavien Howard | MIA | CB | 10 | 218 | 83 | 1 |
| Darius Slay | PHI | CB | 9 | 0 | 0 | 2 |
| Patrick Peterson | - | CB | 9 | 161 | 130 | 1 |
| Joey Porter Jr. | PIT | CB | 7 | 40 | 49 | 0 |
| Daxton Hill | CIN | DB, S | 7 | 29 | 0 | 2 |
| Keisean Nixon | LV | CB, DB | 7 | 63 | 51 | 1 |
| Avonte Maddox | PHI | CB | 6 | 0 | 0 | 0 |
| Emmanuel Moseley | DET | CB, DB | 6 | 178 | 116 | 3 |
| Emmanuel Forbes | WAS | CB | 6 | 30 | 0 | 0 |
